Study suggests link between higher prenatal PFAS exposures and offspring

Research suggests hyperlink between larger prenatal PFAS exposures and offspring weight problems danger in adolescence

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A brand new Venture Viva examine demonstrates the affect of prenatal per- and polyfluoroalkyl substance (PFAS) exposures on kids. The examine, published within the December 6 problem of Environmental Well being Views, noticed a powerful hyperlink between larger prenatal PFAS publicity and elevated charges of weight problems and physique fats in adolescent offspring, additional defining and including depth to their colloquial identify: “perpetually chemical compounds.”

The examine, “Associations of prenatal per- and polyfluoroalkyl substance (PFAS) exposures with offspring adiposity and physique composition at 16-20 years of age: Venture Viva,” was led by researchers on the Harvard Pilgrim Well being Care Institute.

PFAS are generally present in ingesting water and client merchandise equivalent to non-stick cookware, meals packaging, and waterproof clothes and are infamous for his or her persistent nature within the atmosphere. Whereas it’s well-documented that PFAS publicity could cause varied well being considerations equivalent to cardiovascular points, little is understood about how prenatal publicity could affect offspring, and the way lengthy these impacts could comply with them into adolescence and past.

The researchers studied 545 mother-offspring pairs from Venture Viva, a Boston-based cohort now getting into its twenty fifth 12 months. Utilizing PFAS chemical measurements within the moms’ blood samples collected throughout being pregnant and weight and physique composition measurements of their offspring (now 16–20 years previous), the crew used novel statistical strategies to look at how PFAS chemical compounds interacted with one another and the way PFAS chemical compounds together elevated the chance of weight problems and affected the youngsters’s physique composition.

“Using the trove of information from Venture Viva, one of many largest and longest-running pediatric cohorts within the U.S., we have been in a position to embody an extended follow-up time than prior research on this matter and likewise measure adolescent offspring physique composition,” stated senior writer Marie-France Hivert, Harvard Medical College affiliate professor of inhabitants medication on the Harvard Pilgrim Well being Care Institute. “We additionally analyzed PFAS mixtures, including to the clear associations present in single pollutant fashions of different research.”

The examine crew discovered that for larger ranges of sure PFAS in maternal blood, the chance of weight problems within the kids elevated notably—13% to 59%. Kids with larger prenatal PFAS exposures demonstrated extra fast BMI will increase starting round 11th of September years previous, throughout puberty. This hyperlink, the authors say, stuffed a crucial hole in illustrating the long-term penalties of PFAS for developmental well being, particularly within the realm of the weight problems epidemic.

“Stopping and treating childhood weight problems is notoriously troublesome; figuring out and focusing on novel early-life environmental elements which will trigger it are particularly essential. PFAS are known as ‘perpetually chemical compounds’ as a result of they’re ‘perpetually’ persistent within the atmosphere. Our examine confirmed that their prenatal well being results can also have a long-lasting affect,” says Mingyu Zhang, a former analysis fellow on the Harvard Pilgrim Well being Care Institute and lead writer of the examine.

Dr. Zhang, now a Harvard Medical College college member at Beth Israel Deaconess Medical Heart, provides, “Our findings have important public well being implications, and spotlight the necessity for stricter laws on PFAS utilization and additional analysis into greatest practices for mitigating their affect—particularly on weak populations.”

Extra data:
Associations of Prenatal Per- and Polyfluoroalkyl Substance (PFAS) Exposures with Offspring Adiposity and Physique Composition at 16–20 Years of Age: Venture Viva, Environmental Well being Views (2023). DOI: 10.1289/EHP12597. ehp.niehs.nih.gov/doi/10.1289/ehp12597

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Harvard Medical College


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Research suggests hyperlink between larger prenatal PFAS exposures and offspring weight problems danger in adolescence (2023, December 8)
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