Research suggests statins may slow the progression of Alzheimer's disease

Analysis suggests statins might sluggish the development of Alzheimer’s illness

dementia
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Statins may sluggish the development of Alzheimer’s illness, at the very least for some sufferers. That is the results of a brand new research led by Karolinska Institutet revealed in Alzheimer Analysis and Remedy. However the researchers are cautious of their interpretations and see the outcomes as a primary step in a analysis journey that will finally present the reply.

A brand new research reveals that folks with Alzheimer’s dementia deteriorated extra slowly of their cognitive capabilities in the event that they have been additionally handled with a lipid-lowering statin, in comparison with those that weren’t handled. Nonetheless, the research is an observational research the place the researchers have in contrast information on the sufferers from a registry and due to this fact can’t reply whether or not there actually is a causal relationship. Thus, the researchers are cautious of their interpretations.

“Folks with Alzheimer’s dementia handled with statins had higher cognitive improvement over time. Nonetheless, the outcomes of the research don’t imply that we now have proof that folks with dementia must be handled with statins. However however, we will not see any help for not doing so. So, if an individual wants statins for prime blood lipids, a dementia prognosis mustn’t cease the therapy,” says Sara Garcia-Ptacek, docent of neuroscience and assistant professor on the Division of Neurobiology, Care Sciences and Society, and analysis chief of the present research.

The rationale she emphasizes security is that statins have been initially suspected of inflicting confusion in sufferers with dementia. There has due to this fact been some resistance to prescribing statins to those sufferers.

The research included information from greater than 15,500 sufferers with dementia who additionally had a sign for lipid-lowering therapy. Nearly 11,000 of them have been handled with statins. On the whole, the sufferers who have been handled with statins had barely increased values within the cognitive exams carried out, regardless that they have been extra prone to have diagnoses corresponding to hypertension, heart problems and diabetes, all of that are danger components for dementia.

Garcia-Ptacek explains that the analysis workforce began with a speculation that statins may sluggish the development of dementia and solid a reasonably extensive web to see if they may discover proof of this.

“The essential thought of this research was to pave the way in which for a extra exact cohort research that would finally result in a scientific intervention research, which is what is required to show a causal hyperlink between statins and cognition,” says Garcia-Ptacek.

The concept statins may have an effect on the danger or development of dementia shouldn’t be new. There have even been some scientific research accomplished, however they’ve all been detrimental.

“We imagine that solely sure sufferers with Alzheimer’s dementia might profit from statins and that earlier scientific trials have been too small to indicate any important variations. Our thought is to attempt to crystallize which affected person teams profit essentially the most and why, earlier than embarking on scientific trials,” says Garcia-Ptacek.

Extra info:
Statins and cognitive decline in sufferers with Alzheimer’s and combined dementia: A longitudinal registry-based cohort research, Alzheimer Analysis & Remedy (2023). DOI: 10.1186/s13195-023-01360-0

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Karolinska Institutet


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