Popular blood thinner associated with higher risk of bleeding complications

Well-liked blood thinner related to increased threat of bleeding problems

blood clots
Credit score: Pixabay/CC0 Public Area

When recognized with a blood clot or atrial fibrillation, sufferers are sometimes prescribed anticoagulants, or blood thinners, to forestall a future clot.

In a research of the three mostly prescribed blood thinners, the oral anticoagulant rivaroxaban, recognized by the model identify Xarelto, was related to a considerably increased threat of bleeding problems than apixaban (model identify Eliquis) and warfarin for sufferers with blood clots or atrial fibrillation.

The findings, reported at the 2023 American Society of Hematology’s Annual Meeting & Exposition and revealed within the journal Blood, coated over ten years of affected person knowledge from the Michigan Anticoagulation High quality Enchancment Initiative registry. The multi-center initiative is sponsored by Blue Cross Blue Defend of Michigan.

“We discovered the best charges of bleeding amongst sufferers who took rivaroxaban, adopted by warfarin after which apixaban,” mentioned Jordan Ok. Schaefer, M.D., first creator and medical affiliate professor of hematology on the College of Michigan Medical Faculty.

“We adopted sufferers for over two years on common and will examine apixaban to rivaroxaban, one thing that has not but been accomplished in a randomized medical trial. Whereas the findings needs to be confirmed with randomized research, they could have implications for suppliers as they choose anticoagulants for his or her sufferers.”

By way of their evaluation, researchers discovered that if 100 sufferers have been adopted over one 12 months, rivaroxaban resulted in practically 40 bleeding occasions in comparison with round 25 for warfarin. Bleeding occasions have been comparable between apixaban and warfarin, however the latter remedy was related to extra main bleeds.

The speed of blood clots was increased with apixaban in comparison with warfarin, however researchers say it appeared largely pushed by different thrombotic occasions, which included occasions like coronary heart assaults.

Of the three drugs, apixaban was related to a decrease mortality fee than rivaroxaban and warfarin.

“These three drugs are essentially the most generally prescribed anticoagulants for thrombosis and atrial fibrillation, and it’s important that we proceed to analyze the potential impact they carry as we try and greatest serve our sufferers,” mentioned Geoffrey Barnes, M.D., M.Sc., senior creator and affiliate professor of cardiology-internal medication at U-M Medical Faculty.

Extra info:
Jordan Ok Schaefer et al, A Comparability of Bleeding Occasions Amongst Sufferers on Apixaban, Rivaroxaban, and Warfarin for Atrial Fibrillation and/or Venous Thromboembolism, Blood (2023). DOI: 10.1182/blood-2023-184457

Journal info:

Offered by
College of Michigan

Well-liked blood thinner related to increased threat of bleeding problems (2023, December 14)
retrieved 17 December 2023

This doc is topic to copyright. Aside from any honest dealing for the aim of personal research or analysis, no
half could also be reproduced with out the written permission. The content material is offered for info functions solely.

Add a Comment

Your email address will not be published. Required fields are marked *