Drug-drug interactions seen in 21.4% of children with medication exposure

Drug-drug interactions seen in 21.4% of kids with treatment publicity

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Drug-drug interactions seen in 21.4 percent of children with meds exposure

Greater than 20% of kids with two or extra treatment exposures expertise main drug-drug interactions (DDIs) yearly, in line with a examine printed on-line Jan. 4 in Pediatrics.

Kathryn E. Kyler, M.D., from Kids’s Mercy Kansas Metropolis in Missouri, and colleagues carried out a cross-sectional examine of kids aged 0 to 18 years with a number of ambulatory encounter and two or extra distributed outpatient prescriptions to look at the prevalence of main DDI publicity and components related to increased DDI publicity charges amongst youngsters in an outpatient setting. Knowledge had been included for 781,019 youngsters with two or extra treatment exposures.

The researchers discovered that 21.4% of the kids skilled a number of main DDI exposures. Elevated odds of DDI publicity had been seen in affiliation with age and with medical and psychological well being complexity.

Clonidine, psychiatric medicines, and bronchial asthma medicines had been regularly implicated medicine. Per 100 youngsters included, the best hostile physiologic impact publicity price was for elevated drug concentrations, central nervous system melancholy, and coronary heart rate-corrected QT interval prolongation (14.6, 13.6, and 9.9, respectively).

“Prescribers ought to take into account how and when to counsel sufferers concerning the danger of hostile drug occasions related to DDIs, or when to easily monitor for hostile drug occasions in sufferers knowingly uncovered to DDIs when the chance/profit steadiness is favorable,” the authors write.

Extra data:
Kathryn E. Kyler et al, Main Drug–Drug Interplay Publicity Amongst Medicaid-Insured Kids within the Outpatient Setting, Pediatrics (2024). DOI: 10.1542/peds.2023-063506

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