Dexmedetomidine cuts incidence of postpartum despair after C-section

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Dexmedetomidine cuts incidence of postpartum depression after C-section

For ladies with prenatal despair present process cesarean supply, dexmedetomidine reduces the incidence of constructive postpartum despair (PPD) screening, in line with a examine published on-line Jan. 25 in JAMA Community Open.

Yingyong Zhou, Ph.D., from The Third Xiangya Hospital of Central South College in Changsha, China, and colleagues carried out a randomized medical trial involving 338 ladies who screened constructive for prenatal despair and have been scheduled for elective cesarean supply at two hospitals to evaluate the efficacy and security of dexmedetomidine for prevention of PPD. A complete of 338 individuals have been randomly assigned in a 1:1 ratio to obtain dexmedetomidine or saline, infused for 10 minutes after supply. After infusion, sufentanil or dexmedetomidine plus sufentanil was administered for 48 hours within the management and dexmedetomidine teams, respectively.

The researchers discovered that the incidence of constructive PPD screening at seven and 42 days postpartum was considerably decreased within the dexmedetomidine group versus the management group (day 7: 12.6 versus 32.1%; threat ratio, 0.39; day 42: 11.4 versus 30.3%; threat ratio, 0.38). No important distinction was seen between the teams by way of opposed occasions, however an elevated incidence of hypotension was seen within the dexmedetomidine group (18.3 versus 9.5%; threat ratio, 2.15).

“Preventive administration of dexmedetomidine within the early postpartum interval decreased the incidence of constructive PPD screening, decreased postoperative ache, improved sleep high quality, and maintained a positive security profile,” the authors write. “Its antidepressant impact could also be associated to brain-derived neurotrophic issue upregulation and/or downregulation of pro-brain-derived neurotrophic issue.”

Extra data:
Yingyong Zhou et al, Impact of Dexmedetomidine on Postpartum Despair in Girls With Prenatal Despair, JAMA Community Open (2024). DOI: 10.1001/jamanetworkopen.2023.53252

2024 HealthDay. All rights reserved.

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